Pratik Shah

Real-World Translation of Medical Technology

Real-World Translation of Medical Technology

Dr. Shah and his research lab have significant expertise and motivation to bring problems from the clinic and society into the laboratory to develop novel bioengineering solutions and perform real world prospective clinical evaluations. The lab has supported patients and physicians by providing innovative medical technologies using mobile phones, microfluidics, and digital devices for generating at home and point-of-care real world data and evidence.

  • For example in a study led by Dr. Shah his lab, in collaboration with Harvard School of Public Health, published in the British Medical Journal evaluated the significance and efficacy of real world data generated from the United States Food and Drug Administration approved advanced technology-enabled, non-invasive diagnostic screening (TES) smartphones and other point-of-care medical imaging devices vs. conventional vital signs examinations (Project and publication link). This study led to significant insights regarding strategies for developing TES technologies that are ready for deployment and designed for effective and scalable primary care and real-world evidence generation.
  • Dr. Shah is the Co-Principal Investigator in a collaboration with MIT Mechanical Engineering for developing an affinity ligand-based whole-cell capture, concentration, and culture for sensitive pathogen detection food safety tests. This microfluidic microbiological assay is suitable for implementation in an integrated bench top device for use by moderately-trained technicians directly at production sites in a format that preserves cells for further downstream testing (Project link).
  • In collaboration with MIT Chemical Engineering and other researchers Dr. Shah contributed to developing and publishing biochemistry protocols for a lateral flow diagnostic strip and bio-digital wearable devices to detect biomarkers in human saliva samples. Biomarkers such as matrix metalloproteinases-8 and -9, pH and nitric oxide linked to oral diseases, stress and human physiology have been successfully integrated with our platforms (Project and publication link).
  • A study of a low-cost mask to screen for sleep apnea through physiological monitoring: respiratory activity (airflow and nasal air pressure) and sleep behavior (motion and noise) was published (Project and publication link).
  • Dr. Shah led research projects in his lab that reported construction and validation of low-cost, point-of-care, near-infrared imaging devices to diagnose dental caries, cracks, and demineralization without the use of ionizing X-rays (Project and publication link, Project and publication link, Project and publication link).
  • Dr. Shah’s research lab in collaboration with MIT Medical and Tufts School of Medicine has open-sourced the construction and the algorithm of porphyrin and other imaging device, and created a cell phone clip that can be used on a mobile phone camera (Project and publication link).

2018

Technology-enabled examinations evaluated jointly with routine health screenings: an observational study at the 2015 Kumbh Mela in India

Pratik Shah*, Yauney G, Gupta O, Patalano V, Mohit M, Merchant R, Subramanian SV

(*Senior author supervising research, Contributed equally)

The British Medical Journal Open. PMID: 29678964

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2017

Detection of biomarkers of periodontal disease in human saliva using stabilized, vertical flow immunoassays

Emma Yee, Lathwal S, Shah P, Sikes H

ACS Sensors. PMID: 29090909

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2019

Wearable Lab on Body: Combining Sensing of Biochemical and Digital Markers in a Wearable Device

Pat Pataranutaporn, Jain A, Johnson C, Shah P, Maes P

41st IEEE International Engineering in Medicine and Biology Conference (Accepted for publication)

2016

Design and preliminary evaluation of a wearable device for mass screening of sleep apnea

Rohan Puri, Athanasios A, Gill N, Sathya S, Rathod G, Wahi A, Satat G, Majmudar M, Shah P*

(*Senior author supervising research)

Conf Proc IEEE Eng Med Biol Soc. PMID: 28268691

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2019

Digital reconstruction of teeth using near-infrared light

Keith Angelino, Yauney G, Rana A, Muftu A, Edlund D, Shah P*

(*Senior author supervising research)

41st IEEE International Engineering in Medicine and Biology Conference. DOI: 10.1109/EMBC.2019.8857734

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2017

Near-infrared transillumination guides administration of dental 2D radiography and CBCT imaging

Keith Angelino, Edlund D, Bhatia G, Wu S, Shah P*

(*Senior author supervising research, Selected for oral presentation)

17th annual IEEE International Conference on BioInformatics and BioEngineering. DOI: 10.1109/BIBE.2017.00-33

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2017

Near-infrared imaging for detecting caries and structural deformities in teeth

Keith Angelino, Edlund D and Shah P*

(*Senior author supervising research)

Journal of Translational Engineering in Health and Medicine. PMID: 28507826

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2017

Clinical validation and assessment of a modular fluorescent imaging system and algorithm for rapid detection and quantification of dental plaque

Pratik Shah*, Angelino K, Edlund D, Mohit M, Yauney G

(*Senior author supervising research, Contributed equally)

BMC Oral. PMID: 29284461

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Resources

  • R1 - On-site Analysis of Foodborne Pathogens Using Density-Shift Immunomagnetic Separation and Culture [Link]

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